Ignite New Mitochondria
It is shown that high intensity exercise can produce new mitochondria (the powerhouse of the cell) in humans. This is fantastic news for those with autoimmunity, fatigue, and advancing age. Mitochondria are more than energy generators as Terry Wahls provides evidence in her conquer of M.S.
"During endurance, most...of the energy derived from the oxidation of metabolic fuels and ATP hydrolysis of muscle contraction is liberated as heat, the accumulation of which leads to an increase in body temperature. For example, the temperature of exercising muscles can rise to 14 celcius. Although severe heat injury can be deleterious, several beneficial effects of mild heat stress (HS), such as the improvement of insulin sensitivity in patients with type 2 diabetes, have been reported. However, among all cellular events induced by mild HS from physical activities, the direct effects and mechanisms of mild HS on mitochondrial biogenesis in skeletal muscle are least characterized. AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) are key energy-sensing molecules regulating mitochondrail biogenisis. In C2C12 myotubes, we fouond that 1 h mild HS at 40 celcius upregulated both AMPK activity and SIRT1 expression, as well as increased the expression of several mitochondria biogenesis regulatory genes including peroxisome proliferator-activated receptor gamma coactivator...and transcription factors involved in mitochondria biogenesis. In particular,...expression was found to be transcriptionally regulated by mild HS. Additionally, after repeated mild HS for 5 days, protein levels.. and several mitochondrial oxidative phosphorylation subunits were also upregulated. Repeated mild HS also significantely increased mitochondrial DNA copy number. In conclusion, these data show that mild HS is sufficient to induce mitochondrial biogenesis in C2C12 myotubes. Temperature-induced mitochondrial biogenesis correlates with activation of the... pathway. Therefore, it is possible that muscle heat production during exercise plays a role in mitochondrial biogenesis."
Thank you Chris Highcock
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